Article
Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.
The Journal of biological chemistry - 23 Oct 1998
Yoshida L S, Saruta F, Yoshikawa K, Tatsuzawa O, Tsunawaki S
Abstract excerpt
Defective NADPH oxidase components prevent superoxide (O-2) generation, causing chronic granulomatous disease (CGD). X-linked CGD patients have mutations in the gene encoding the gp91(phox) subunit of cytochrome b558 and usually lack gp91(phox) protein completely (X91(0)). gp91(phox) is considere...
Topics
- Amino Acid Sequence
- Binding Sites
- Biological Transport
- Child, Preschool
- Cytochrome b Group
- Cytosol
- Ferredoxin-NADP Reductase
- Flavin-Adenine Dinucleotide
- Genetic Linkage
- Granulomatous Disease, Chronic
- Heme
- Histidine
- Humans
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutation