Article
Glucocorticoid-suppressible hyperaldosteronism: effects of crossover site and parental origin of chimaeric gene on phenotypic expression.
Clinical science (London, England : 1979) - 1 May 1995
Jamieson A, Slutsker L, Inglis G C, Fraser R, White P C, Connell J M
Abstract excerpt
1. Genetic analysis of five kindreds with glucocorticoid-suppressible hyperaldosteronism, four of whom had not been subjected to any previous genetic analysis, revealed three different crossover breakpoints within the five kindreds clustered in the exon 3-intron 4 region of the chimaeric gene. The site of the crossover point had no effect on blood pressure within the kindreds studied. 2. The gene causing...
Topics
- Adolescent
- Adult
- Base Sequence
- Child
- Child, Preschool
- Chimera
- Crossing Over, Genetic
- Cytochrome P-450 CYP11B2
- Cytochrome P-450 Enzyme System
- Female
- Genotype