Article
GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
Carcinogenesis - 1 Jul 1995
Perrett C W, Clayton R N, Pistorello M, Boscaro M, Scanarini M, Bates A S, Buckley N, Jones P, Fryer A A, Gilford J
Abstract excerpt
We describe studies to determine if susceptibility to pituitary tumours is associated with the putatively high risk GSTM1 null and CYP2D6 EM genotypes. Frequency distributions of these genotypes were similar in cases and controls though the frequency of CYP2D6 PM and GSTM1 B tended to be lower (P = 0.072 and P = 0.095 respectively) in the tumour group. Immunopositivity for p53 was found in 18/97 tumours. In these...
Topics
- Adult
- Aged
- Alleles
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- GTP-Binding Proteins
- Gene Expression
- Genes, Tumor Suppressor
- Genes, p53
- Genes, ras
- Genotype