Article
A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
Pharmacogenetics - 1 Dec 1997
Kelsey K T, Wrensch M, Zuo Z F, Miike R, Wiencke J K
Abstract excerpt
Previous studies of associations of metabolic polymorphisms with the occurrence of malignant brain tumors have suggested that there is a significantly increased risk of development of adult gliomas in individuals who carry a poor metabolizer CYP2D6 variant allele and the GSTT1 null genotype. To i...
Topics
- Adult
- Brain Neoplasms
- Case-Control Studies
- Cytochrome P-450 CYP2D6
- Female
- Genotype
- Glioma
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
