Article
A cell type-specific silencer in the human choline acetyltransferase gene requiring two distinct and interactive E boxes.
Brain research. Molecular brain research - 1 May 1995
Li Y P, Baskin F, Davis R, Wu D, Hersh L B
Abstract excerpt
We have previously reported that cholinergic neuron-specific expression of the human choline acetyltransferase gene is mediated by two co-operative silencers. We have now localized the proximal silencer to the region from nucleotide -2195 to -2409, which contains two distinct E boxes (CACCTG and CATGTG). Deletion or mutation of either of these E boxes results in a loss of silencer activity. There are specific...
Topics
- Base Sequence
- Choline O-Acetyltransferase
- DNA Probes
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Neuroblastoma
- Neurons
- Regulatory Sequences, Nucleic Acid
- Tumor Cells, Cultured