Article
Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1995
Krenger W, Snyder K M, Byon J C, Falzarano G, Ferrara J L
Abstract excerpt
Acute graft-vs-host disease (GVHD) is thought to be mediated by alloreactive T cells with a type 1 cytokine phenotype. To prevent the development of acute GVHD, we have successfully polarized mature donor T cells toward a type 2 cytokine phenotype ex-vivo by incubating them with murine rIL-4 in a...
Topics
- Animals
- Bone Marrow Transplantation
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Female
- Graft Survival
- Graft vs Host Disease
- Immunization, Passive
- Immunophenotyping
- Interferon-gamma
- Interleukin-4
- Lipopolysaccharides
- Lymphocyte Culture Test, Mixed
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Phenotype