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Article

Biochemical characteristics of human pituitary somatotropinomas with and without gsp mutations: in vitro cell culture studies.

The Journal of clinical endocrinology and metabolism - 1 Jul 1995

Adams E F, Lei T, Buchfelder M, Petersen B, Fahlbusch R

Abstract excerpt

Gsp oncogenes are present in about 40% of somatotropinomas. They result in excessive cAMP production and have been proposed to be the cause of increased GH secretion. We have used in vitro cell culture to compare the biochemical characteristics of somatotropinomas with and without gsp oncogenes (gsp-positive and gsp-negative tumors, respectively). Of 30 somatotropinomas examined, 10 proved to be gsp positive, as...

Topics

Base Sequence
Growth Hormone
Growth Hormone-Releasing Hormone
Humans
Molecular Sequence Data
Mutation
Octreotide
Oncogenes
Phosphatidylinositols
Pituitary Neoplasms
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7608258
DOI: 10.1210/jcem.80.7.7608258

Genes

GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7608258-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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