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Article

Contribution of residue 192 in factor Xa to enzyme specificity and function.

The Journal of biological chemistry - 7 Jul 1995

Rezaie A R, Esmon C T

Abstract excerpt

Mutation of residue 192 (chymotrypsin numbering) from Glu to Gln in thrombin and activated protein C has been shown to dramatically alter substrate and inhibitor specificity, in large part by allowing these enzymes to accept substrates with acidic residues in the P3 and/or P3' positions. In factor Xa, residue 192 is already a Gln. We now compare the properties of a Q192E mutant of Gla-domainless factor X (GDFX)....

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Identifiers

PMID: 7608183
DOI: 10.1074/jbc.270.27.16176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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