[Direct detection of loci with pathologic trinucleotide repeats in diseases with anticipation].

Article

[Direct detection of loci with pathologic trinucleotide repeats in diseases with anticipation].

Genetika - 1 Apr 1995

Rogaev E I, Rogaeva E A, Dzhordzh-Khislop P

Abstract excerpt

We describe a simple method for the identification of pathologically expanded (CCG)n and (CTG)n three nucleotides repeat arrays in the human genome and for the recovery of flanking sequences. We were able to detect the presence of novel high-molecular-weight alleles in at least two of three subje...

Topics

Alleles
Chromosome Mapping
Genome, Human
Humans
Molecular Weight
Nucleic Acid Hybridization
Oligonucleotides
Repetitive Sequences, Nucleic Acid

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