Linker histones are not essential and affect chromatin condensation in vivo.

doi:10.1016/0092-8674(95)90051-9

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Article

Linker histones are not essential and affect chromatin condensation in vivo.

Cell - 14 Jul 1995

Shen X, Yu L, Weir J W, Gorovsky M A

Abstract excerpt

We have (separately) disrupted all of the expressed macronuclear copies of the HHO gene encoding macronuclear histone H1 and of the micronuclear linker histone (MLH) gene encoding the protein MicLH in Tetrahymena thermophila. These disruptions are shown to eliminate completely the expression of e...

Topics

Animals
Base Sequence
Cell Nucleus
Chromatin
DNA, Protozoan
Genes, Protozoan
Histones
Interphase
Micronucleus, Germline
Mitosis
Molecular Sequence Data
Mutation
RNA, Messenger
RNA, Protozoan
Tetrahymena thermophila

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