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Article

Linker histones are not essential and affect chromatin condensation in vivo.

Cell - 14 Jul 1995

Shen X, Yu L, Weir J W, Gorovsky M A

Abstract excerpt

We have (separately) disrupted all of the expressed macronuclear copies of the HHO gene encoding macronuclear histone H1 and of the micronuclear linker histone (MLH) gene encoding the protein MicLH in Tetrahymena thermophila. These disruptions are shown to eliminate completely the expression of each protein. Strains without either linker histone grow at normal rates and reach near-normal cell densities,...

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Identifiers

PMID: 7606784
DOI: 10.1016/0092-8674(95)90051-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linker histones are not essential and affect chromatin condensation in vivo.PMID 7606784Read ↗

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Deposition and function of histone H3 variants in Tetrahymena thermophila.Semantic proximity Read ↗

Histone H1 variant, H1R is involved in DNA damage response.Semantic proximity Read ↗

Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome.Semantic proximity Read ↗

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