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Article

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.

Science (New York, N.Y.) - 30 Jun 1995

Drummond J T, Li G M, Longley M J, Modrich P

Abstract excerpt

A mismatch-binding heterodimer of hMSH2 and a 160-kilodalton polypeptide has been isolated from HeLa cells by virtue of its ability to restore mismatch repair to nuclear extracts of hMSH2-deficient LoVo colorectal tumor cells. This heterodimer, designated hMutS alpha, also restores mismatch repair to extracts of alkylation-tolerant MT1 lymphoblastoid cells and HCT-15 colorectal tumor cells, which are selectively...

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Source

Identifiers

PMID: 7604264
DOI: 10.1126/science.7604264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.PMID 7604264Read ↗

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSαSemantic proximity Read ↗

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.Semantic proximity Read ↗

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damageSemantic proximity Read ↗

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair.Semantic proximity Read ↗

Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch RepairSemantic proximity Read ↗

Mismatch repair deficiency associated with overexpression of the <i>MSH3</i> geneSemantic proximity Read ↗

Mismatch Recognition and DNA-dependent Stimulation of the ATPase Activity of hMutSα Is Abolished by a Single Mutation in the hMSH6 SubunitSemantic proximity Read ↗

Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.Semantic proximity Read ↗

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1Semantic proximity Read ↗

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.Semantic proximity Read ↗

Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteinsSemantic proximity Read ↗

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