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Article

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.

Science (New York, N.Y.) - 30 Jun 1995

Drummond J T, Li G M, Longley M J, Modrich P

Abstract excerpt

A mismatch-binding heterodimer of hMSH2 and a 160-kilodalton polypeptide has been isolated from HeLa cells by virtue of its ability to restore mismatch repair to nuclear extracts of hMSH2-deficient LoVo colorectal tumor cells. This heterodimer, designated hMutS alpha, also restores mismatch repai...

Topics

Amino Acid Sequence
Base Composition
Base Sequence
Colorectal Neoplasms
DNA Damage
DNA Repair
DNA, Neoplasm
DNA-Binding Proteins
HeLa Cells
Humans
Molecular Sequence Data
Molecular Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Heteroduplexes

Sequence Deletion

Tumor Cells, Cultured

Source

Identifiers

PMID: 7604264
DOI: 10.1126/science.7604264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7604264-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Related research

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Click a neighbor to travelStep 1 · 11 closest

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.PMID 7604264Read ↗

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSαSemantic proximity Read ↗

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.Semantic proximity Read ↗

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damageSemantic proximity Read ↗

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair.Semantic proximity Read ↗

Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch RepairSemantic proximity Read ↗

Mismatch repair deficiency associated with overexpression of the <i>MSH3</i> geneSemantic proximity Read ↗

Mismatch Recognition and DNA-dependent Stimulation of the ATPase Activity of hMutSα Is Abolished by a Single Mutation in the hMSH6 SubunitSemantic proximity Read ↗

Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.Semantic proximity Read ↗

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1Semantic proximity Read ↗

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.Semantic proximity Read ↗

Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteinsSemantic proximity Read ↗

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