Article
OXPHOS defects and mitochondrial DNA mutations in cardiomyopathy.
Muscle & nerve. Supplement - 1 Jan 1995
Zeviani M, Mariotti C, Antozzi C, Fratta G M, Rustin P, Prelle A
Abstract excerpt
Defects of the mitochondrial respiratory chain in cardiac muscle are an important, yet still overlooked cause of heart failure. In 16 of 32 endocardial biopsies from infants affected by "idiopathic" hypertrophic cardiomyopathy we demonstrated a remarkable decrease of activity of either complex I, or complex IV, or both, relative to complex II + III activity which was taken as an index of mitochondrial...
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