Mitochondrial diabetes mellitus--glucose-induced signaling defects and beta-cell loss.

doi:10.1002/mus.880181426

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Article

Mitochondrial diabetes mellitus--glucose-induced signaling defects and beta-cell loss.

Muscle & nerve. Supplement - 1 Jan 1995

Oka Y, Katagiri H, Ishihara H, Asano T, Kikuchi M, Kobayashi T

Abstract excerpt

Japanese diabetic patients whose mothers were also diabetic were screened, using peripheral leukocytes, for an A to G transition at nucleotide pair 3243 of the mitochondrial gene, a tRNA(Leu)(UUR) mutation. This mutation was identified in four pedigrees from among 300 unrelated patients. Diabetes...

Topics

Adolescent
Adult
Aged
Base Sequence
DNA, Mitochondrial
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Female
Glucose
Hearing Loss, Sensorineural
Humans
Hypoglycemic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Islets of Langerhans

Male

Middle Aged

Molecular Sequence Data

Mutation

Prospective Studies

Source

Open in PubMed

Identifiers

PMID: 7603514
DOI: 10.1002/mus.880181426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7603514-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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