Article
Phenotypic and pathologic evaluation of the myd mouse. A candidate model for facioscapulohumeral dystrophy.
Journal of neuropathology and experimental neurology - 1 Jul 1995
Mathews K D, Rapisarda D, Bailey H L, Murray J C, Schelper R L, Smith R
Abstract excerpt
Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant disease of unknown pathogenesis which is characterized by weakness of the face and shoulder girdle. It is associated with a sensorineural hearing loss which may be subclinical. FSHD has been mapped to the distal most portion of 4q35, although the gene has not yet been identified. Distal 4q has homology with a region of mouse chromosome 8 to which a...
Topics
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Disease Models, Animal
- Evoked Potentials, Auditory, Brain Stem
- Facial Muscles
- Genotype
- Hearing Loss, Sensorineural
- Humans
- Mice