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Article

Frequent Amplification of the Cyclin E Gene in Human Gastric Carcinomas

1 Jul 1995

Abstract excerpt

We searched for genetic alterations of the cyclin D1 and cyclin E genes in 45 human gastric carcinoma tissues. Expression of cyclin E mRNA and protein was also analyzed in eight of them by Northern and Western blots and immunohistochemical staining. The cyclin E gene was amplified 3-10 fold in seven gastric cancer tissues (15.6%), of which six were advanced gastric cancers. All of the cases with the cyclin E gene...

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Identifiers

PMID: 7559076
DOI: 10.1111/j.1349-7006.1995.tb02442.x

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