Article
Lack of association between the -308 polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Jul 2000
da Sliva B, Gapstur S M, Achenbach Y H, Schuh T S, Kotlar T J, Liu K, Lowe W L
Abstract excerpt
BACKGROUND: Previous studies have demonstrated a role for tumor necrosis factor-alpha (TNF-alpha) in insulin resistance. A polymorphic variant of the TNF-alpha gene, the TNF2 allele, which is a guanine to adenine polymorphism at position -308 in the TNF-alpha promoter, is associated with higher basal and inducible promoter activity. The present study examined whether the TNF2 allele was associated with altered...
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