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Article

Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

The Journal of experimental medicine - 1 Nov 1995

Cabrera M, Shaw M A, Sharples C, Williams H, Castes M, Convit J, Blackwell J M

Abstract excerpt

Recent studies have shown that mucocutaneous leishmaniasis (MCL), a severe and debilitating form of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis infection, is accompanied by high circulating levels of tumor necrosis factor (TNF)-alpha. Analysis of TNF polymorphisms in Venezuelan ACL patients and endemic unaffected controls demonstrates a high relative risk (RR) of 7.5 (P < 0.001) of...

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Identifiers

PMID: 7595196
DOI: 10.1084/jem.182.5.1259
PMCID: PMC2192198

Genes

TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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