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Article

Severe Adverse Drug Reactions to Quetiapine in Two Patients Carrying CYP2D6*4 Variants: A Case Report.

International journal of molecular sciences - 17 Jun 2021

Stäuble Céline K, Lampert Markus L, Mikoteit Thorsten, Hatzinger Martin, Hersberger Kurt E, Meyer Zu Schwabedissen Henriette E

Abstract excerpt

We report two cases of patients who developed severe adverse drug reactions including persistent movement disorders, nausea, and vertigo during treatment with quetiapine at maximum daily doses ranging between 300 and 400 mg. The extensive hepatic metabolism of quetiapine is mainly attributed to cytochrome P450 3A4 (CYP3A4). However, there is recent evidence supporting the idea of CYP2D6 playing a role in the...

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Identifiers

PMID: 34204223
DOI: 10.3390/ijms22126480
PMCID: PMC8233787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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