Article
Tumor necrosis factor-alpha and X-linked adrenoleukodystrophy.
Journal of neuroimmunology - 1 Sept 1995
McGuinness M C, Griffin D E, Raymond G V, Washington C A, Moser H W, Smith K D
Abstract excerpt
The two most common forms of X-linked adrenoleukodystrophy (X-ALD), the childhood cerebral form (CCER) and the adult form, adrenomyeloneuropathy (AMN), arise from the same mutations in the X-ALD gene at Xq28. These two forms are distinguished by the degree of cerebral inflammation. Segregation analysis suggests that an autosomal modifying gene may be a major determinant of phenotype in X-ALD. Thus, a modifying...
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