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Article

Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.

PloS one - 1 Jan 2012

Thibert Kathryn A, Raymond Gerald V, Nascene David R, Miller Weston P, Tolar Jakub, Orchard Paul J, Lund Troy C

Abstract excerpt

BACKGROUND: X-linked adrenoleukodystrophy results from mutations in the ABCD1 gene disrupting the metabolism of very-long-chain fatty acids. The most serious form of ALD, cerebral adrenoleukodystrophy (cALD), causes neuroinflammation and demyelination. Neuroimaging in cALD shows inflammatory changes and indicates blood-brain-barrier (BBB) disruption. We hypothesize that disruption may occur through the...

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Source

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Identifiers

PMID: 23185624
DOI: 10.1371/journal.pone.0050430
PMCID: PMC3503955

Genes

MMP10
TIMP1
MMP9
ABCD1
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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