1-Methylguanosine deficiency of tRNA influences cognate codon interaction and metabolism in Salmonella typhimurium.

Abstract excerpt

1-Methylguanosine (m1G) is present next to the 3' end of the anticodon (position 37) in tRNA(1,2,3,Leu), tRNA(1,2,3,Pro), and tRNA(3Arg). A mutant of Salmonella typhimurium lacks m1G in these seven tRNAs when grown at or above 37 degrees C, as a result of a mutation (trmD3) in the structural gene (trmD) for the tRNA(m1G37)methyltransferase. The m1G deficiency induced 24 and 26% reductions in the growth rate and...

Topics

• 3-Isopropylmalate Dehydrogenase
• Alcohol Oxidoreductases
• Amino Acid Transport Systems, Neutral
• Amino Acids
• Bacterial Proteins
• Carbon
• Codon
• Drug Resistance, Microbial
• Enzyme Induction
• Gene Expression Regulation, Bacterial