Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase–mediated p53 phosphorylation and stabilization

1 Apr 2007

Abstract excerpt

Luteolin is an important flavonoid with a potential anticancer effect. In this study, we examined the molecular mechanisms involved in the sensitization effect of luteolin on cancer cell killing induced by cisplatin, an important cancer chemotherapeutic agent. First, we provided evidence that the sensitization effect of luteolin on cisplatin-induced apoptosis is p53 dependent, as such effect is only found in p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17431112
DOI: 10.1158/1535-7163.mct-06-0638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase–mediated p53 phosphorylation and stabilizationPMID 17431112Read ↗

Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent PathwaySemantic proximity Read ↗

Lutein inhibits tumor progression through the ATR /Chk1/p53 signaling pathway in non‐small cell lung cancerSemantic proximity Read ↗

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cellsSemantic proximity Read ↗

The Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin PatentsSemantic proximity Read ↗

Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: Involvement of cell line‐specific apoptotic mechanismsSemantic proximity Read ↗

Breast Cancer Apoptosis and the Therapeutic Role of LuteolinSemantic proximity Read ↗

Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of CancerSemantic proximity Read ↗

MicroRNA-6809-5p mediates luteolin-induced anticancer effects against hepatoma by targeting flotillin 1Semantic proximity Read ↗

Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells.Semantic proximity Read ↗

Rutin Mediated Apoptotic Cell Death in Caski Cervical Cancer Cells via Notch-1 and Hes-1 DownregulationSemantic proximity Read ↗

Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis.Semantic proximity Read ↗

Luteolin is effective in the non-small cell lung cancer model with L858R/T790M EGF receptor mutation and erlotinib resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.