Article
The SH2-containing adapter protein GRB10 interacts with BCR-ABL.
Oncogene - 27 Aug 1998
Bai R Y, Jahn T, Schrem S, Munzert G, Weidner K M, Wang J Y, Duyster J
Abstract excerpt
Bcr-Abl is an oncogenic tyrosine kinase expressed in tumor cells of CML and a subset of ALL which in its unregulated and activated state is thought to cause cell transformation and leukemia. Bcr-Abl contains several autophosphorylation sites which serve as potential docking sites for SH2-containi...
Topics
- Absorption
- Cell Line
- Cell Transformation, Neoplastic
- Enzyme Activation
- ErbB Receptors
- Fusion Proteins, bcr-abl
- GRB10 Adaptor Protein
- Genetic Vectors
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mutation
- Protein Binding
- Protein-Tyrosine Kinases
- Proteins
- Saccharomyces cerevisiae
- Transfection
- Tumor Cells, Cultured
- src Homology Domains