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Article

The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function.

The Journal of biological chemistry - 28 Feb 2003

Foucault Isabelle, Liu Yun-Cai, Bernard Alain, Deckert Marcel

Abstract excerpt

Lymphocyte stimulation by immunoreceptors is achieved through the activation of multiple signaling pathways leading to cytokine gene transcription. Adapter proteins are critical signaling components that can integrate multiple pathways by allowing the assembly of multimolecular signaling complexes. We previously showed that the cytoplasmic adapter 3BP2 (also known as SH3BP2) promotes NFAT/AP-1 transcriptional...

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Identifiers

PMID: 12501243
DOI: 10.1074/jbc.M209509200

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