Article
[Correlation studies on the alterations of multiple tumor suppressor genes in human esophageal cancer and in human and monkey esophageal epithelial cells treated with N-methyl-N-benzyl nitrosamine].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Jul 1995
Li H, Lu S, Cui X
Abstract excerpt
The correlation between the mutation spectra of tumor suppressor genes Rb, p53, APC and MCC in human esophageal cancer (EC) and in human and monkey esophageal epithelium treated with N-Methyl-N-Benzyl nitrosamine (NMBzA) was studied using PCR amplification and direct sequencing methods. The resul...
Topics
- Animals
- Carcinogens
- Dimethylnitrosamine
- Epithelium
- Esophageal Neoplasms
- Genes, APC
- Genes, MCC
- Genes, Retinoblastoma
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Macaca mulatta
- Mutation
- Polymerase Chain Reaction