Article
Mutations of O6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China.
International journal of cancer - 29 May 1997
Wang L, Zhu D, Zhang C, Mao X, Wang G, Mitra S, Li B F, Wang X, Wu M
Abstract excerpt
Epidemiologic studies have implicated the involvement of environmental factors in the etiology of esophageal cancer (EC). Our previous data have indicated that EC patients and their blood relatives show genomic instability and are deficient in repair of DNA damage induced by N-nitroso-compounds and related genotoxic agents. Thus, exposure to high levels of N-alkylnitrosamines, which are known animal carcinogens...
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