Article
Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells.
Nature medicine - 1 Jul 1995
Chen J, Willingham T, Margraf L R, Schreiber-Agus N, DePinho R A, Nisen P D
Abstract excerpt
To investigate how overexpression of MAD, an antagonist of MYC oncogenes influences the malignant phenotype of human cancer cells, an adenovirus vector system was used to transfer the human MAD gene (AdMAD) into human astrocytoma cells. Decreased growth potential of AdMAD-infected cells was evide...
Topics
- Animals
- Astrocytoma
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Basic-Leucine Zipper Transcription Factors
- Brain Neoplasms
- Burkitt Lymphoma
- Carcinoma
- Carcinoma, Squamous Cell
- Cell Adhesion
- Cell Cycle
- Cell Division
- DNA Replication
- DNA, Neoplasm
- DNA-Binding Proteins