Article
In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells.
Cancer investigation - 1 Jul 2020
Das Arabinda, Martinez Santos Jaime L, Alshareef Mohammed, Porto Guilherme Bastos Ferreira, Infinger Libby Kosnik, Vandergrift William A, Lindhorst Scott M, Varma Abhay K, Patel Sunil J, Cachia David
Abstract excerpt
Background: Meningiomas represent ∼30% of primary central nervous system (CNS) tumors. Although advances in surgery and radiotherapy have significantly improved survival, there remains an important subset of patients whose tumors have more aggressive behavior and are refractory to conventional therapy. Recent advances in molecular genetics and epigenetics suggest that this aggressive behavior may be due to the...
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