Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells

3 Feb 2009

Abstract excerpt

Abacavir is one of the most efficacious nucleoside analogues, with a well-characterized inhibitory activity on reverse transcriptase enzymes of retroviral origin, and has been clinically approved for the treatment of AIDS. Recently, Abacavir has been shown to inhibit also the human telomerase activity. Telomerase activity seems to be required in essentially all tumours for the immortalization of a subset of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19358275
DOI: 10.1002/ijc.24331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cellsPMID 19358275Read ↗

RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cellsSemantic proximity Read ↗

Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYCSemantic proximity Read ↗

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in MedulloblastomaSemantic proximity Read ↗

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma NeurospheresSemantic proximity Read ↗

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.Semantic proximity Read ↗

Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells.Semantic proximity Read ↗

Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain TumorsSemantic proximity Read ↗

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signalingSemantic proximity Read ↗

Effect of low doses of actinomycin D on neuroblastoma cell linesSemantic proximity Read ↗

AZT as a telomerase inhibitorSemantic proximity Read ↗

HIV and drug abuse mediate astrocyte senescence in a β‐catenin‐dependent manner leading to neuronal toxicitySemantic proximity Read ↗

Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.