Lines of Murine Oligodendroglial Precursor Cells Immortalized by an Activated <i>neu</i> Tyrosine Kinase Show Distinct Degrees of Interaction with Axons <i>In Vitro</i> and <i>In Vivo</i>

Abstract excerpt

Replication-defective retroviruses expressing the t-neu oncogene, or a hybrid protein with the neu tyrosine kinase linked to the external region of the human epidermal growth factor receptor (egfr-neu), were used to establish lines of murine oligodendroglial precursor cells. Differentiation of the t-neu lines into myelin-associated glycoprotein (MAG)-positive oligodendrocytes was induced by dibutyryl cAMP, and...

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