Olfactory neuronal cell lines generated by retroviral insertion of the n-myc oncogene display different developmental phenotypes.

doi:10.1002/(SICI)1097-4547(19960801)45:3<237::AID-JNR5>3.0.CO;2-E

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Article

Olfactory neuronal cell lines generated by retroviral insertion of the n-myc oncogene display different developmental phenotypes.

Journal of neuroscience research - 1 Aug 1996

MacDonald K P, Mackay-Sim A, Bushell G R, Bartlett P F

Abstract excerpt

Being genetically homogeneous, clonal cell lines are potentially important for investigating many aspects of cellular differentiation. We describe here the creation of clonal cell lines by immortalization of neuronal precursor cells from the adult mouse olfactory epithelium. Unlike neurons elsewhere in the vertebrate nervous system, the olfactory sensory neuron can be replaced throughout the lifespan of the...

Topics

Animals
Blotting, Northern
Cell Line
Clone Cells
Coloring Agents
DNA Transposable Elements
Electrophoresis, Polyacrylamide Gel
Genes, myc
Genetic Markers
Genetic Vectors
Immunohistochemistry
Mice
Mice, Inbred C57BL
Neurons

Source

Open in PubMed

Identifiers

PMID: 8841984
DOI: 10.1002/(SICI)1097-4547(19960801)45:3<237::AID-JNR5>3.0.CO;2-E

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Olfactory Mucosa

Phenotype

RNA, Viral

Retroviridae