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Article

Role of light chain variable region in myeloma with light chain deposition disease: evidence from an experimental model

15 Nov 1995

Abstract excerpt

Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both encoded by the unique V kappa IV gene. Mice secreting the LCDD chain but not those producing the...

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Identifiers

PMID: 7579330
DOI: 10.1182/blood.v86.10.3655.bloodjournal86103655

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