Article
p53 protein expression and p53 gene mutation in thymic epithelial tumors. An immunohistochemical and DNA sequencing study.
American journal of clinical pathology - 1 Oct 1995
Tateyama H, Eimoto T, Tada T, Mizuno T, Inagaki H, Hata A, Sasaki M, Masaoka A
Abstract excerpt
p53 protein expression in 34 thymic epithelial tumors was examined immunohistochemically, and p53 gene mutation was detected in selected cases by DNA sequencing, using formalin-fixed and paraffin-embedded tissues. The tumors comprised 12 noninvasive thymomas, 9 invasive/metastatic thymomas, and 1...
Topics
- Adult
- Aged
- Base Sequence
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Neoplasm Invasiveness
- Neoplasms, Glandular and Epithelial
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Sequence Analysis, DNA
- Thymus Neoplasms