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Article

Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.

Journal of virology - 1 Feb 1996

Carrillo A, Ratner L

Abstract excerpt

Insertion of T-cell line-tropic V3 and V4 loops from the HXB2 strain into the macrophage-tropic YU-2 envelope resulted in a virus with delayed infectivity for HUT78 and Jurkat cells compared with HXB2. Sequence analysis of viral DNA derived from long-term cultures of Jurkat cells revealed a specific mutation that changed a highly conserved Asn residue in the V1 loop of Env to an Asp residue (N-136-->D)....

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Identifiers

PMID: 8551601
DOI: 10.1128/JVI.70.2.1310-1316.1996
PMCID: PMC189949

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