Article
Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.
Journal of virology - 1 Feb 1996
Carrillo A, Ratner L
Abstract excerpt
Insertion of T-cell line-tropic V3 and V4 loops from the HXB2 strain into the macrophage-tropic YU-2 envelope resulted in a virus with delayed infectivity for HUT78 and Jurkat cells compared with HXB2. Sequence analysis of viral DNA derived from long-term cultures of Jurkat cells revealed a speci...
Topics
- Amino Acid Sequence
- Cloning, Molecular
- Gene Products, env
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Kinetics
- Membrane Fusion
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Recombinant Fusion Proteins
- T-Lymphocytes
- Tumor Cells, Cultured
- Vaccinia virus
- beta-Galactosidase