Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.

Science (New York, N.Y.) - 10 Apr 1992

Raymond M, Gros P, Whiteway M, Thomas D Y

Abstract excerpt

Multidrug resistance in mammalian tumor cells is associated with the overexpression of mdr genes encoding P-glycoproteins, which function as drug efflux pumps. A yeast homolog of mdr, STE6, mediates export of a-factor mating peptide. Yeast MATa cells carrying a ste6 deletion produce no extracellular a-factor and therefore are defective in mating. Expression of a complementary DNA for the mouse mdr3 gene in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Crosses, Genetic
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Mutation

Share to Plasmids

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 1348873
DOI: 10.1126/science.1348873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.PMID 1348873Read ↗

A Ste6p/P‐glycoprotein homologue from the asexual yeast <i>Candida albicans</i> transports the a‐factor mating pheromone in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.Semantic proximity Read ↗

Expression of MFA1 and STE6 is sufficient for mating type-independent secretion of yeast a-factor, but not mating competence.Semantic proximity Read ↗

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.Semantic proximity Read ↗

Mating of the fission yeast occurs independently of pmd1+ gene product, a structural homologue of budding yeast STE6 and mammalian P-glycoproteins.Semantic proximity Read ↗

Mutations within the first LSGGQ motif of Ste6p cause defects in a-factor transport and mating in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor.Semantic proximity Read ↗

Role of the ABC transporter Ste6 in cell fusion during yeast conjugation.Semantic proximity Read ↗

The yeast a-factor transporter Ste6p, a member of the ABC superfamily, couples ATP hydrolysis to pheromone export.Semantic proximity Read ↗

Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.Semantic proximity Read ↗

A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans.Semantic proximity Read ↗

Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.