Article
Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.
Science (New York, N.Y.) - 10 Apr 1992
Raymond M, Gros P, Whiteway M, Thomas D Y
Abstract excerpt
Multidrug resistance in mammalian tumor cells is associated with the overexpression of mdr genes encoding P-glycoproteins, which function as drug efflux pumps. A yeast homolog of mdr, STE6, mediates export of a-factor mating peptide. Yeast MATa cells carrying a ste6 deletion produce no extracellular a-factor and therefore are defective in mating. Expression of a complementary DNA for the mouse mdr3 gene in a...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Amino Acid Sequence
- Animals
- Chromosome Deletion
- Crosses, Genetic
- Drug Resistance
- Genes, Fungal
- Genetic Complementation Test
- Mating Factor
- Membrane Glycoproteins