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Article

Genotypic analysis of multiple loci in somatic cells by whole genome amplification.

Nucleic acids research - 11 Sept 1995

Barrett M T, Reid B J, Joslyn G

Abstract excerpt

To screen multiple loci in small purified samples of diploid and aneuploid cells a PCR-based technique of whole genome amplification was adapted to the study of somatic lesions. DNA samples from different numbers of flow-sorted diploid and aneuploid cells from biopsies were amplified with a degenerate 15mer primer. Aliquots of these reactions were then used in locus-specific reactions using a single round of PCR...

Topics

Adenocarcinoma
Alleles
DNA, Neoplasm
Esophageal Neoplasms
Genetic Markers
Humans
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
Sequence Deletion

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Identifiers

PMID: 7567460
DOI: 10.1093/nar/23.17.3488
PMCID: PMC307228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7567460-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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