Duchenne-like myopathy in double-mutant mdx mice expressing exaggerated mast cell activity.

Abstract excerpt

Dystrophin-deficient female mdx mice were bred with male Tsk+/+ pa mice to examine the role played by mast cells in the pathophysiology of dystrophin deficiency. Resultant mdx/Tsk double-mutant mice were then examined functionally, biochemically, and histologically. While mdx mice remained as strong as their normal counterparts, mdx/Tsk double-mutant mice became progressively weak with age. Serum creatine kinase...

Topics

• Animals
• Chymases
• Creatine Kinase
• Dystrophin
• Female
• Male
• Mast Cells
• Mice
• Mice, Mutant Strains
• Muscle, Skeletal
• Muscular Dystrophy, Animal
• Mutation