Article
Eosinophilia of dystrophin-deficient muscle is promoted by perforin-mediated cytotoxicity by T cell effectors.
The American journal of pathology - 1 May 2000
Cai B, Spencer M J, Nakamura G, Tseng-Ong L, Tidball J G
Abstract excerpt
Previous investigations have shown that cytotoxic T lymphocytes (CTLs) contribute to muscle pathology in the dystrophin-null mutant mouse (mdx) model of Duchenne muscular dystrophy through perforin-dependent and perforin-independent mechanisms. We have assessed whether the CTL-mediated pathology includes the promotion of eosinophilia in dystrophic muscle, and thereby provides a secondary mechanism through which...
Topics
- Adoptive Transfer
- Animals
- Anti-Inflammatory Agents
- Cell Transplantation
- Cytotoxicity, Immunologic
- Dystrophin
- Eosinophilia
- Eosinophils
- Female
- Leukocyte Count
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Inbred mdx