Article
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.
The Journal of clinical investigation - 1 Mar 2011
Goonasekera Sanjeewa A, Lam Chi K, Millay Douglas P, Sargent Michelle A, Hajjar Roger J, Kranias Evangelia G, Molkentin Jeffery D
Abstract excerpt
Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders characterized by progressive muscle wasting and often premature death. The primary defect common to most MDs involves disruption of the dystrophin-glycoprotein complex (DGC). This leads to sarcolemmal instability and Ca(2+) influx, inducing cellular necrosis. Here we have shown that the dystrophic phenotype observed in δ-sarcoglycan–null...
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