Article
Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases alpha and epsilon.
The Journal of biological chemistry - 29 Sept 1995
Møller N P, Møller K B, Lammers R, Kharitonenkov A, Hoppe E, Wiberg F C, Sures I, Ullrich A
Abstract excerpt
Binding of insulin to its receptor (IR) causes rapid autophosphorylation with concomitant activation of its tyrosine kinase which transmits the signal by phosphorylating cellular substrates. The IR activity is controlled by protein-tyrosine phosphatases, but those directly involved in regulating the insulin receptor and its signaling pathways have not yet been identified. Using baby hamster kidney cells...
Topics
- Animals
- Cell Division
- Cell Line
- Cricetinae
- Down-Regulation
- Gene Expression
- Humans
- Insulin
- Isoenzymes
- Kidney
- Kinetics
- Phenotype