Article
HLA-DRB, -DQA, and -DQB polymorphism in celiac disease and enteropathy-associated T-cell lymphoma. Common features and additional risk factors for malignancy.
Human immunology - 1 May 1995
Howell W M, Leung S T, Jones D B, Nakshabendi I, Hall M A, Lanchbury J S, Ciclitira P J, Wright D H
Abstract excerpt
CD is a gluten-sensitive enteropathy, strongly associated with expression of the DQA1*0501, DQB1*0201 genotype. CD patients have an increased risk of malignancy, particularly EATCL. However, it is controversial as to whether adults with EATCL represent a subgroup of patients with CD or should be regarded as a distinct entity. To investigate the genetic relationship between CD and EATCL, HLA class II DRB1, DQA1,...
Topics
- Adolescent
- Adult
- Age Factors
- Celiac Disease
- Child, Preschool
- Female
- Gastrointestinal Neoplasms
- Gene Frequency
- Genes, MHC Class II
- Genotype
- HLA-DQ Antigens