Myocardial phenotypic changes in Na+, K+ ATPase in left ventricular hypertrophy: pharmacological consequences.

doi:10.1093/eurheartj/16.suppl_c.20

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Article

Myocardial phenotypic changes in Na+, K+ ATPase in left ventricular hypertrophy: pharmacological consequences.

European heart journal - 1 May 1995

Charlemagne D, Swynghedauw B

Abstract excerpt

Cardiac adaptation to permanent overload induces several phenotypic changes which finally result in a system which works more economically, together with a slower Vmax. The molecular target of digitalis is the NA+, K+ ATPase, which is a polymorphic molecule. We have recently demonstrated that dur...

Topics

Animals
Calcium
Cardiotonic Agents
Digitalis Glycosides
Glycosides
Humans
Hypertrophy, Left Ventricular
Myocardium
Phenotype
Rats
Sodium-Potassium-Exchanging ATPase

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