Article
Effects of chronic growth hormone excess on cardiac contractility and myosin phenotype in the rat.
Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Sept 1992
Timsit J, Mercadier J J
Abstract excerpt
The effects of chronic growth hormone (GH) hypersecretion on intrinsic contractile properties of the myocardium were studied in rats bearing a GH-secreting tumour. Body weight and heart weight increased, but no true cardiac hypertrophy was observed. The maximum active force of left ventricular papillary muscle was increased, and the maximum shortening velocity of the unloaded muscle was unaltered. This was...
Topics
- Animals
- Female
- Growth Hormone
- Heart
- Myocardial Contraction
- Myocardium
- Myosins
- Organ Size
- Phenotype
- RNA, Messenger
- Rats
- Rats, Inbred WF