Article
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
Molecular and cellular biochemistry - 1 Jan 2002
Jäger Doris, Müller-Werdan Ursula, Pönicke Klaus, Holtz Jürgen, Werdan Karl, Müller Sylvana P
Abstract excerpt
Because of its key role in proteosynthesis, the total content of elongation factor-2 (EF-2) and the distribution of six main EF-2 variants were investigated after Pseudomonas Exotoxin A catalyzed [37P]ADP-ribosylation using 1D-PAGE and isoelectric focusing (IEF) in a rat model of hemodynamic overload with variable degrees of cardiac hypertrophy: Chronic NO-synthase inhibition by L-NAME...
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