Article
The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.
Development (Cambridge, England) - 1 Feb 1996
Wightman B, Clark S G, Taskar A M, Forrester W C, Maricq A V, Bargmann C I, Garriga G
Abstract excerpt
The assembly of the nervous system in the nematode C. elegans requires the directed migrations of cells and growth comes along the anteroposterior and dorsoventral body axis. We show here that the gene vab-8 is essential for most posteriorly directed migrations of cells and growth cones. Mutations in vab-8 disrupt fourteen of seventeen posteriorly directed migrations, but only two of seventeen anteriorly directed...
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