Article
Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations.
Clinical pharmacology and therapeutics - 1 Sept 1995
Brannan M D, Reidenberg P, Radwanski E, Shneyer L, Lin C C, Cayen M N, Affrime M B
Abstract excerpt
OBJECTIVE: To evaluate the effects of coadministration of loratadine and erythromycin on the pharmacokinetics and electrocardiographic repolarization (QTc) pharmacodynamics of loratadine and its metabolite descarboethoxyloratadine in healthy volunteers. METHODS: Twenty-four healthy volunteers were studied in a prospective, double-blind crossover design while confined in a Clinical Research Center. The primary...
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