Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations.

doi:10.1016/0009-9236(95)90243-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations.

Clinical pharmacology and therapeutics - 1 Sept 1995

Brannan M D, Reidenberg P, Radwanski E, Shneyer L, Lin C C, Cayen M N, Affrime M B

Abstract excerpt

OBJECTIVE: To evaluate the effects of coadministration of loratadine and erythromycin on the pharmacokinetics and electrocardiographic repolarization (QTc) pharmacodynamics of loratadine and its metabolite descarboethoxyloratadine in healthy volunteers. METHODS: Twenty-four healthy volunteers wer...

Topics

Adult
Anti-Bacterial Agents
Cross-Over Studies
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Drug Interactions
Drug Therapy, Combination
Electrocardiography
Erythromycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Evaluation Studies as Topic

Genotype

Histamine H1 Antagonists

Humans

Loratadine

Male

Mixed Function Oxygenases

Source

Open in PubMed

Identifiers

PMID: 7554700
DOI: 10.1016/0009-9236(95)90243-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7554700-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations.PMID 7554700Read ↗

Pharmacokinetic Drug-Drug Interactions of DA-8010 with Clarithromycin or Rifampicin: Influence of CYP2D6 Phenotype on the Extent of These Interactions.Semantic proximity Read ↗

Evaluation of the effects of AZD3480 on cardiac repolarization: a thorough QT/QTc study using moxifloxacin as a positive control.Semantic proximity Read ↗

Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects.Semantic proximity Read ↗

Pharmacokinetic interactions between omeprazole/pantoprazole and clarithromycin in health volunteers.Semantic proximity Read ↗

Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin.Semantic proximity Read ↗

Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World PracticeSemantic proximity Read ↗

Antihistamines: past answers and present questions.Semantic proximity Read ↗

Doxepin Drug-Drug and Drug-Gene Interactions: Clinical Implications and Mechanistic InsightsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.