Article
Antihistamines: past answers and present questions.
Current drug safety - 1 Jan 2010
Keller Guillermo Alberto, Di Girolamo Guillermo
Abstract excerpt
Antihistamines are drugs frequently used. Several drugs in this family had to be withdrawn from the market or limited in their marketing due to potentially fatal adverse events. These events were related to the ability of some antihistamines to affect cardiac potassium channels and prolong the QT interval with an excessive risk of serious arrhythmias such as Torsades de Pointes (TdP). The presence of arrhythmias...
Topics
- Animals
- Dose-Response Relationship, Drug
- Drug Interactions
- Electrocardiography
- Genetic Predisposition to Disease
- Histamine Antagonists
- Humans
- Long QT Syndrome
- Polymorphism, Genetic
- Potassium Channels
- Risk Factors
- Torsades de Pointes