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Article

Pharmacokinetic Drug-Drug Interactions of DA-8010 with Clarithromycin or Rifampicin: Influence of CYP2D6 Phenotype on the Extent of These Interactions.

Drug design, development and therapy - 1 Jan 2026

Lee Sujong, Won Heejae, Yu Kyung-Sang, Lee Dae Young, Lee SeungHwan

Abstract excerpt

Purpose: This study aimed to evaluate the pharmacokinetic (PK) drug-drug interactions (DDIs) of DA-8010 with clarithromycin or rifampicin, and to assess the influence of cytochrome P450 (CYP) 2D6 phenotype on the extent of these interactions. Methods: An open-label, fixed-sequence, three-period crossover study was conducted in healthy participants. Participants received a single dose of DA-8010 5 mg alone on Day...

Topics

Adult
Female
Humans
Male
Middle Aged
Young Adult
Clarithromycin
Cross-Over Studies
Cytochrome P-450 CYP2D6
Drug Interactions
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Healthy Volunteers

Phenotype

Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 42094211
DOI: 10.2147/DDDT.S592783
PMCID: PMC13142728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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