Effect of dietary fat or tamoxifen on the expansion of cells harboring Ha-ras oncogenes in mammary glands from methylnitrosourea-treated rats.

doi:10.1093/carcin/16.9.2281

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Article

Effect of dietary fat or tamoxifen on the expansion of cells harboring Ha-ras oncogenes in mammary glands from methylnitrosourea-treated rats.

Carcinogenesis - 1 Sept 1995

Hu Z, Chaulk J E, Lu S J, Xu Z, Archer M C

Abstract excerpt

Diets containing high levels of fat enhance the formation of methylnitrosourea (MNU)-induced mammary gland adenocarcinomas in rats, while administration of the antiestrogen tamoxifen decreases the incidence of these tumors. It is not known, however, at what stage during tumor development the fat...

Topics

Animals
Antineoplastic Agents, Hormonal
Carcinogens
Cell Division
Dietary Fats
Female
Genes, ras
Mammary Glands, Animal
Methylnitrosourea
Mutation
Polymerase Chain Reaction
Rats
Tamoxifen

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