Article
R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation.
The Journal of nutrition - 1 Jul 2001
Robinson L E, Clandinin M T, Field C J
Abstract excerpt
Because anticancer immunity declines progressively with tumor growth, a major focus of current research in tumor immunology is the development of means to stimulate the host immune system. This study determined the effects of dietary long-chain (n-3) fatty acids and tumor burden on immune cell phospholipid composition and membrane-mediated immune defense in rats implanted with the R3230AC mammary adenocarcinoma....
Topics
- Adenocarcinoma
- Animal Feed
- Animals
- Cell Membrane
- Cytokines
- Fatty Acids, Omega-3
- Female
- Fluorescent Antibody Technique, Indirect
- Immunophenotyping
- Lymphocyte Activation
- Mammary Neoplasms, Experimental
- Mitogens
- Phenotype
- Phosphatidylethanolamines
- Rats
- Rats, Inbred F344
- Receptors, Interleukin-2
- Spleen